FTHALIDE STANDARD
Fthalide
CAS: 27355-22-2
Molecular Formula: C8H2Cl4O2
FTHALIDE STANDARD - Names and Identifiers
| Name | Fthalide |
| Synonyms | Fthalide KASURABCIDE fthalide (jmaf) phthalide (jmaf) FTHALIDE STANDARD Fthalide Phthalide 3,4,5,6-tetrachlorophthalide |
| CAS | 27355-22-2 |
| EINECS | 608-088-8 |
FTHALIDE STANDARD - Physico-chemical Properties
| Molecular Formula | C8H2Cl4O2 |
| Molar Mass | 271.91 |
| Density | 1.767±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 209.5℃ |
| Boling Point | 381.73°C (rough estimate) |
| Storage Condition | 0-6°C |
| Refractive Index | 1.5282 (estimate) |
| Physical and Chemical Properties | Pure product is white crystal. M. p.209 ~ 210 ℃, the solubility at 25 ℃ is: tetrahydrofuran 19.3g/L, benzene 14.1g/L, acetone 8.3g/L, ethanol 1.1g/L, water 2.49mg/L. It is stable to light, heat, acid, and weak base, but azeotropic with strong lye, it decomposes and destroys the ester ring. Complete decomposition after 180d in soil. |
FTHALIDE STANDARD - Risk and Safety
| Toxicity | LD50 oral in rat: 20gm/kg |
FTHALIDE STANDARD - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | Acute oral LD50>10000mg/kg in rats and mice, acute percutaneous LD50>10000mg/kg, there was no irritation to rabbit skin and eyes. The subacute non-acting dose of rabbit is 2000mg/kg per day, the maximum safe concentration is 2000mg/kg, and the minimum toxic concentration is 10000mg/kg. In the test dose, found no carcinogenic, teratogenic, mutagenic effects. Carp LC50>135mg/L(320mg/L) (48h). Low toxicity to birds, low toxicity to bees and silkworm. |
| Application | is a protective fungicide against Rice blast. Before the pathogen invades the rice plant, it can effectively inhibit the spore formation on the surface of the rice plant and prevent the invasion of the mycelium, so it has a good control effect, however, if the rice blast fungus invaded the rice plant and then applied, it could not prevent the germination of spores or the growth of hyphae. For the prevention and control of panicle neck blast, the first spraying shall be carried out during the break stage of rice, and the water shall be sprayed with 50% wettable powder 15g/100m2, and 7d after the panicle stage or the first spraying, the second spraying was performed, and the residual effect reached 13d. For the prevention and control of leaf blast, spray on the spot in the field, spray with 50% wettable powder 15g/100m2 on water, if the disease is still developing, spray again after 5-7 days, the control effect was 70% ~ 90%. |
| production method | preparation method-benzene ring chlorination with carbon tetrachloride as solvent (3320g), in the presence of catalyst, 223g(2mol) of O-xylene was added, and after mixing, chlorine reaction was performed, and the reaction was controlled at less than 60 ° C., and the reaction was carried out for 3H to precipitate white crystals. The temperature was raised to 70 ° C., and chlorine continued to be applied until most of the crystals were dissolved. After the end of the side chain chlorobenzene ring chlorination, slightly cold, take out the iron catalyst to add phosphorus trichloride 20g, under high pressure mercury lamp light chlorine, (can also be in azobisisobutyronitrile and phosphorus trichloride side chain chlorination in the presence of) reaction was carried out at 70 ° C. For 7h, and tetrachloro carbon was distilled off to obtain about 780g of product. Synthesis of tetrachlorophenphthalein after mixing 100g of g3,4,5,6-α,α,α',α'-octacloro-o-xylene and 95% of sulfuric acid with stirring, the mixture is increased to 130~140 ℃, heat preservation for 5H, until no hydrogen chloride gas escapes, cool to room temperature, then slowly pour into ice water, precipitate light yellow crystals, suction filter, wash and dry to give about 70g of tetrachlorobenzophthalein. Preparation Method 2 |
| category | pesticide |
| toxicity grade | low toxicity |
| Acute toxicity | oral-rat LD50: 20000 mg/kg; Oral-mouse LD50: 10000 mg/kg |
| flammability hazard characteristics | toxic chloride gases from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| extinguishing agent | dry powder, foam, sand |
Last Update：2024-04-09 21:21:28
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